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The binding of clonidine to plasma protein is primarily to albumin and varies between 20 and 40%.Epidurally administered clonidine readily partitions into plasma via the epidural veins and attains systemic concentrations (0.5 to 2.0 ng/m L) that are associated with a hypotensive effect mediated by the central nervous system.CL was 279 ± 184 and 272 ± 163 m L/min on these days.CSF concentrations were not determined in these patients.However, in a rare obstetrical, postpartum or perioperative patient, potential benefits may outweigh the possible risks.Clonidine hydrochloride injection is a centrally-acting analgesic solution for use in continuous epidural infusion devices.

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The pharmacokinetics of epidurally administered clonidine has not been studied in the pediatric population or in patients with renal or hepatic disease.Clonidine's total body clearance (CL) was 219 ± 92 m L/min.Following a 700 mcg clonidine HCl epidural dose given over five minutes to four male and five female volunteers, peak clonidine plasma levels (4.4 ± 1.4 ng/m L) were obtained in 19 ± 27 minutes.Following an intravenous dose of C-clonidine, 72% of the administered dose was excreted in urine in 96 hours of which 40 to 50% was unchanged clonidine.Renal clearance for clonidine was determined to be 133 ± 66 m L/min.




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